Does Vitamin D3 interact with statins?

Growing scientific evidence suggests that vitamin D₃–drug interactions may impact specific patient groups and increase their risk of low vitamin D status, particularly those prescribed medications like statins and corticosteroids.

Can you take Vitamin D3 with statins?

No interactions were found between atorvastatin and Vitamin D3.

What vitamins should not be taken with statins?

Certain supplements may benefit people who take statins. For example, there is some evidence that taking supplements of coenzyme Q10 may reduce the muscle soreness that statins sometimes cause. However, taking niacin (vitamin B3) supplements along with a statin medication may worsen muscle soreness.

What medications should not be taken with Vitamin D3?

Possible interactions include:

• Aluminum. ...
• Anticonvulsants. ...
• Atorvastatin (Lipitor). ...
• Calcipotriene (Dovonex, Sorilux). ...
• Cholestyramine (Prevalite). ...
• Cytochrome P-450 3A4 (CYP3A4) substrates. ...
• Digoxin (Lanoxin). ...
• Diltiazem (Cardizem, Tiazac, others).

Does vitamin D affect cholesterol medication?

157 +/- 37, P < 0.005) were lower during vitamin D supplementation. The conclusion of the study is that vitamin D supplementation lowers atorvastatin and active metabolite concentrations yet has synergistic effects on cholesterol concentrations.

Does vitamin D3 raise cholesterol?

Higher vitamin D levels appear to be associated with higher total cholesterol levels and higher HDL cholesterol levels, according to a new study presented at the American College of Cardiology's (ACC) 65th Annual Scientific Sessions.

Can you take vitamin D if you are taking statins?

Vitamin D supplement may have moderate or no effect on the dosage requirement or side effects of pravastatin, rosuvastatin and pitavastatin. Since vitamin D has mild HMG-CoA reductase activity, it will work synergistically with all statins.

Is it OK to take vitamin D3 everyday?

Most experts recommend that you shouldn't take more than 4,000 IU of vitamin D a day. When your serum D3 is very low (less than 12 nanograms per milliliter), some may recommend a short course of once-weekly 50,000 IU of vitamin D2 or D3, followed by a usual dose of 600 to 800 IU daily.

Does D3 interact with anything?

Critical vitamin D3-drug interactions

Several commonly prescribed medications have a negative impact on vitamin D status. Medications most likely to affect the status or actions of vitamin D3 include those used to manage hyperlipidemia, arthritis, diabetes, depression, asthma, and COPD⁵.

What is the difference between vitamin D and vitamin D3?

There are two possible forms of vitamin D in the human body: vitamin D2 and vitamin D3. Both D2 and D3 are simply called “vitamin D,” so there's no meaningful difference between vitamin D3 and just vitamin D.

What supplements should I take with a statin?

Coenzyme Q10 (CoQ10), a nutrient produced by the body and used for cellular energy, is often touted as being vital if you're taking statin drugs to lower cholesterol. Proponents of CoQ10 say it helps reduce muscle pain, which can be a side effect of statin use, and is an important energy source that the body needs.

How long does it take for a statin to lower cholesterol?

You should see major changes in your cholesterol levels within two to four weeks after starting treatment. When you take a statin, you do more than improve your cholesterol levels. They also reduce your risk of heart attack, stroke, and other heart problems.

Can I take a multivitamin with statins?

No interactions were found between Daily Multi-Vitamins with Minerals and simvastatin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

How much Vitamin D3 should I take?

All things considered, a daily vitamin D intake of 1,000–4,000 IU, or 25–100 micrograms, should be enough to ensure optimal blood levels in most people. According to the National Institutes of Health, the safe upper limit is 4,000 IU.

How does vitamin D affect atorvastatin?

Vitamin D induced CYP3A4, reducing active concentrations of atorvastatin and its metabolites. This reduction should produce an increase in cholesterol and LDL cholesterol levels.

What is the best time to take vitamin D3?

Better Absorbed With Meals

For this reason, it's recommended to take vitamin D supplements with a meal to enhance absorption. According to one study in 17 people, taking vitamin D with the largest meal of the day increased vitamin D blood levels by about 50% after just 2–3 months ( 7 ).

Does taking vitamin D interfere with any medications?

Does vitamin D interact with other medications? Yes. Steroid medications such as prednisone can interfere with vitamin D metabolism. If you take steroid drugs regularly, discuss vitamin D with your doctor.

Is 5000 IU vitamin D3 OK?

In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.

How much vitamin D should a 65 year old take?

Adults aged up to 70 years old should be getting at least 600 IU. Adults older than 70 should be getting at least 800 IU of vitamin D.

Is it better to take vitamin D3 every day or once a week?

The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective.

How much vitamin D3 is too much?

Taking 60,000 international units (IU) a day of vitamin D for several months has been shown to cause toxicity. This level is many times higher than the U.S. Recommended Dietary Allowance (RDA) for most adults of 600 IU of vitamin D a day.

When should you stop taking vitamin D?

Do not take more than 100 micrograms (4,000 IU) of vitamin D a day as it could be harmful. This applies to adults, including pregnant and breastfeeding women and the elderly, and children aged 11 to 17 years. Children aged 1 to 10 years should not have more than 50 micrograms (2,000 IU) a day.

Can I take Vitamin D3 with Crestor?

Interactions between your drugs

No interactions were found between Crestor and Vitamin D3.

What can I take instead of statins to lower cholesterol?

7 cholesterol-lowering alternatives to statins

• Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. ...
• Plant stanols and sterols. ...
• Cholestyramine and other bile acid-binding resins. ...
• Niacin. ...
• Policosanol. ...
• Red yeast rice extract (RYRE) ...
• Natural products.

What is the best vitamin to take to lower cholesterol?

Niacin. This B vitamin can boost HDL “good" cholesterol and lower LDL “bad” cholesterol and triglycerides -- but only use it if your doctor advises you to. Only prescription-level doses impact cholesterol and triglycerides.